Images from organ systems:
Nervous System to Respiratory System

Organ System

Histopathology
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Nervous system

Peripheral nerve.
121

Nervous system

Alzheimer’s disease (AD). Microscopically, a triad of distinctive histologic changes characterizes AD: neurofibrillary tangles, senile plaque formation, and granulovacuolar degeneration. Neurofibrillary changes in cortical neurons are closely associated with intellectual deterioration. Luxol fast blue (LFB) stain shows skeins of neurofibrillary tangles that wrap around the nucleus and branch into the neuritic process. 91

Nervous system

Progressive multifocal leukoencephalopathy (PML or Richardson’s disease). An infection of the cerebral cortex, PML tumor is caused by a papovavirus. It is an opportunistic infection secondary to HIV/AIDS in about 4% of patients, and survival after diagnosis averages about 3 months. 142

Nervous system

Creutzfeldt-Jakob disease (CJD). An infectious disease caused by prions, usually affecting the cerebral cortex and characterized by marked spongiosis with severe neuronal loss and astrocytic gliosis. This is the human variant of bovine spongiform encephalopathy (BSE) known as “mad cow” disease and generally fatal in both species. 73

Oropharynx

Scraping from oral candidiasis (Candida albicans) showing blastoconidia, hyphae, and pseudohyphae. Thrush and leukoplakia appear as a opportunistic mycotic infections secondary to HIV/AIDS. 60
Respiratory system Community-acquired pneumonia. 127
Respiratory system Pulmonary tuberculosis. Caused by acid-fast Mycobacterium tuberculosis is characterized by a granulomatous reaction in the lung, where parenchyma is infiltrated by neutrophils, monocytes, epithelioid cells, and giant Langhan’s cells. Koch’s bacilli are seen as intracellular and extracellular curvilinear organisms. 57
Respiratory system Small cell lung cancer (SCLC) or Oat cell carcinoma of the lung. 80
Respiratory system Non-small cell lung cancer (NSCLC) or Adenocarcinoma of the lung. 91